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Earth’s sixth major mass extinction event has begun and amphibians in particular are in peril; over 40% of amphibian species are threatened with extinction. One agent in their demise is chytrid fungus Batrachochytrium dendrobatidis, responsible for the most widespread, disease-induced declines and extinctions in vertebrates to date. New Guinea is the world’s largest tropical island and the last major center of amphibian biodiversity free from chytrid. Deb Bower, Simon Clulow and their colleagues call for urgent, unified, international, multidisciplinary action to prepare for the arrival of chytrid in New Guinea, to prevent or slow its spread within the island after it arrives, and to limit its impact upon the island’s frog populations.